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Redefining Immunotherapy

Our Science
Innovation

At Rise Therapeutics, we pioneer precision immunotherapy by integrating new immunological discoveries and advanced oral drug delivery approaches to transform immunotherapy drug development. Our synthetic biology-based rational drug design approach drives the development of targeted first-in-class Oral Immune BioModulators, now evolving through clinical validation studies for the treatment of autoimmunity and cancer.
Immunology

Immunology

Unlocking immune programming
 
Rise Therapeutics` Oral Immune BioModulators control and direct immune programming to reset immunological repertoires and correct the root cause of disease. Our products represent a paradigm shift in immunotherapy product development—harnessing foundational immune controls as a gateway to modulate systemic immune function with unprecedented specificity and control.


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From Science to Patients

From Science to Patients

Orchestrating Immune Response
 
Dendritic cells are master regulators of immune function and by directing these immune cell populations via our Oral Immune Biomodulators, we articulate the genesis of selected immune populations that have the potential to correct immunological dysfunction that can cause disease. We validate our dendritic cell targets and their modulators, confirming safety in non-clinical studies, before we evaluate in patients to determine disease improvement mediated by our therapy products.


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Synthetic Biology

Synthetic Biology

Targeted, oral drug delivery
 
As a foundational technology, Rise Therapeutics has developed an innovative and proprietary drug delivery platform that embraces synthetic biology-based approaches to enable oral delivery of targeted biologic therapy. We leverage this proprietary platform for convenient oral capsule administration of our Oral Immune BioModulator products.


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Our Capabilities

INFRASTRUCTURE

Clinical GMP
Manufacturing

Rise Therapeutics integrates regulatory expertise with clinical development and in-house,
state-of-the-art clinical GMP manufacturing, ensuring seamless translation from discovery to
patient-ready immunotherapies
with the highest quality
standards.

CLINICAL TRANSLATION

Product Development

Backed by robust preclinical data, Rise Therapeutics’ Oral BioModulators are advancing through clinical validation studies across multiple indications, offering patients a safe, first-in-class approach to correct underlying immune dysfunction that contributes to disease.

Our Pipeline

At Rise Therapeutics, we drive rapid and efficient drug development by integrating cutting-edge research, in-house GMP manufacturing, and deep clinical and regulatory expertise. Our streamlined approach enables us to translate innovative laboratory discoveries into first-in-class oral immunotherapies, accelerating their journey from concept to clinical validation. By leveraging our proprietary oral drug delivery platform and end-to-end development capabilities, we are advancing a robust pipeline of next-generation immunotherapies for the treatment of autoimmune diseases and cancer.
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Our Team

Gary Fanger, PHDFounder, President & CEO
Gary Fanger, PHD
Christian Furlan Freguia, PhD Senior VP of Research
Christian Furlan  Freguia, PhD
Sathya Janardhanan, MS VP of Manufacturing
Sathya Janardhanan, MS
JANET STEPHENS, PhDSenior VP of Operations
JANET STEPHENS, PhD
SOPHIE CHAPELLE, MSVP of Business Development
SOPHIE CHAPELLE, MS

Interested in working with Us?

Become a Partner

Rise Therapeutics seeks strategic partnerships with academic, biotech, and pharmaceutical leaders committed to advancing groundbreaking immunotherapies and transforming patient care.

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Join Our Team

We are always looking for extraordinary people with exceptional creativity and enthusiasm. In our collaborative, high performing, and entrepreneurial environment, we work as a team to investigate life saving products and treatments.

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Our News

Rockville, Maryland, January 13, 2025 – Rise Therapeutics, a biotechnology company engaged in developing novel oral Immunotherapeutics, today announced that the U.S. Food and Drug Administration (FDA) has accepted its investigational new drug (IND) application to proceed with a cancer Phase 1 clinical trial for its program candidate, R-5780. This is Rise Therapeutics’ fourth clinical program to enter patient clinical testing. For separate products, other clinical studies are ongoing for the treatment of ulcerative colitis, rheumatoid arthritis, and type 1 diabetes.

Rockville, Maryland, January 6th, 2025 – Rise Therapeutics, a clinical-stage biotechnology company developing novel oral immunotherapeutic medicines, today announced that it has completed dose escalation enrollment stages for both its R-2487 and R-3750 clinical trials. Both studies will now initiate the planned dose expansion stages to enroll additional patients at fixed doses.

Rockville, Maryland, October 22nd, 2024- Rise Therapeutics announced today that it has received funding from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institute of Health (NIH) to enable infrastructure improvement that will scale GMP production and accelerate quality assurance (QA) and quality control (QC), significantly enhancing its biologics drug manufacturing capabilities. This Commercial Readiness Pilot (CRP) Program SBIR award will also support Phase 2 clinical GMP manufacturing to advance Rise Therapeutics’ R-3750 program currently completing a Phase 1 proof-of-concept clinical trial in patients suffering from ulcerative colitis.